NCT06985147Phase 2Active not recruiting

A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

Study sponsor: Disc Medicine, Inc · IRON

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2027-02Estimated

Enrollment · participants60Estimated

Source updated2026-07-31Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Posted 2026-07-31 · 1 field changed

Recruitment status

Recorded edit

− Previous value

Recruiting

+ Updated value

Active not recruiting

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Posted 2025-11-24 · 1 field changed

Enrollment · participant count

Recorded edit

− Previous value

count: 20; type: ESTIMATED

+ Updated value

count: 60; type: ESTIMATED

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Study details

Conditions studied

Polycythemia Vera (PV)

Treatments or interventions studied

DISC-3405Drug

Primary outcomes · main study measures

Read the study measures

measure: Number of participants with treatment-related adverse events as assessed by CTCAE; description: Proportion of participants with treatment-emergent adverse events; timeFrame: Up to 365 days; measure: Incidence of clinically abnormal vital signs; description: Proportion of participants with changes in vital signs; timeFrame: Up to 365 days; measure: Incidence of clinically abnormal physical exam; description: Proportion of participants with changes in physical examinations; timeFrame: Up to 365 days; measure: Incidence of clinically abnormal electrocardiograms; description: Proportion of participants with changes in electrocardiograms (ECGs); timeFrame: Up to 365 days; measure: Incidence of abnormal laboratory test results; description: Proportion of participants with changes in clinical laboratory results; timeFrame: Up to 365 days

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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