NCT07553637Phase 2Recruiting

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2027-11Estimated

Enrollment · participants178Estimated

Source updated2026-04-28Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Study details

Conditions studied

Treatment-resistant Depression (TRD)

Treatments or interventions studied

ALTO-207Drug
PlaceboDrug

Primary outcomes · main study measures

Read the study measures

measure: Change in the MADRS total score; description: Montgomery Asberg Depression Rating Scale (MADRS) is a clinician-administered scale designed to measure depression severity and detects changes due to antidepressant treatment. The MADRS evaluates the following 10 items: apparent sadness, reported sadness, inner tension, reduced sleep, reduced appetite, concentration difficulties, lassitude, inability to feel, pessimistic thoughts, and suicidal thoughts. Each item is scored from 0 (item not present or normal) to 6 (severe or continuous presence of the symptoms), for a total possible score of 60. Higher scores represent a more severe condition.; timeFrame: Change from baseline up to 8 weeks

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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