NCT06864104Phase 2Completed

A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2026-01-12Actual

Enrollment · participants206Actual

Source updated2026-03-31Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Posted 2026-03-31 · 1 field changed

Recruitment status changed

− Before

~~Active not recruiting~~

+ After

Completed

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Posted 2026-03-05 · 2 fields changed

Completion date type changed

− Before

~~Estimated~~

+ After

Actual

Primary completion date changed

− Before

~~9 Jan 2026~~

+ After

12 Jan 2026

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Study details

Conditions studied

Hypertension

Treatments or interventions studied

TonlamarsenDrug
PlaceboDrug

Primary outcomes · main study measures

Read the study measures

measure: To assess the effect of tonlamarsen on plasma angiotensinogen (AGT) levels; description: Percent Change from baseline (Week 0) in plasma angiotensinogen (AGT) levels to Week 20; timeFrame: Week 20; measure: To assess the systolic blood pressure-lowering efficacy of tonlamarsen; description: Change from baseline (Week 0) in mean office seated systolic blood pressure to Week 20; timeFrame: Week 20

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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