NCT06672237Phase 3Recruiting

A Phase 3 Study of NTLA-2001 in ATTRv-PN

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2027-07Estimated

Enrollment · participants60Estimated

Source updated2026-04-16Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Posted 2026-04-16 · 2 fields changed

Planned enrollment increased by 10 participants

− Before

~~50 participants (planned)~~

+ After

60 participants (planned)

Recruitment status changed

− Before

~~Active not recruiting~~

+ After

Recruiting

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Posted 2025-11-26 · 1 field changed

Recruitment status changed

− Before

~~Recruiting~~

+ After

Active not recruiting

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Study details

Conditions studied

Neuromuscular Disease; Neuromuscular Diseases (NMD); Neurodegenerative Disease; Neurodegenerative Disease, Hereditary; Neurodegenerative Diseases; Neuromuscular Diseases; Nerve Disorders; Nervous System Disease; Nervous System Diseases; Genetic Disease, Inborn; Amyloidosis, Familial; Amyloidosis, Hereditary; Amyloidosis; Polyneuropathies; Amyloid Neuropathies; Amyloid Neuropathies, Familial; Peripheral Nervous System Disease; Peripheral Nervous System Diseases; Metabolism, Inborn Errors; Metabolic Diseases

Treatments or interventions studied

nexiguran ziclumeranBiologicalAlso known as NTLA-2001
Normal Saline as PlaceboDrug

Primary outcomes · main study measures

measure: Modified Neuropathy Impairment Score +7 (mNIS+7); timeFrame: 18 Months; measure: Serum TTR; timeFrame: 29 Days

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

How to read this history