NCT06196879Phase 2Completed

A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2025-12-16Actual

Enrollment · participants479Actual

Source updated2026-05-01Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Posted 2026-03-27 · 1 field changed

Recruitment status changed

− Before

~~Active not recruiting~~

+ After

Completed

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Posted 2026-02-17 · 2 fields changed

Completion date type changed

− Before

~~Estimated~~

+ After

Actual

Primary completion date changed

− Before

~~19 Feb 2026~~

+ After

16 Dec 2025

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Study details

Conditions studied

Severe Asthma

Treatments or interventions studied

Verekitug (UPB-101)Drug
PlaceboDrug

Primary outcomes · main study measures

Read the study measures

measure: Annual Asthma Exacerbation Rate (AAER); description: An asthma exacerbation is defined as a worsening of asthma that required treatment with systemic (oral or intravenous) corticosteroids for at least three consecutive days or a single depo-injectable dose of corticosteroids or an emergency room (ER) or urgent care visit that required systemic corticosteroids or an admission to an inpatient facility and/or evaluation and treatment in a healthcare facility for greater than or equal to 24 hours.; timeFrame: Baseline up to Week 60

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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