NCT05926765Phase 2Active not recruiting

A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2027-06Estimated

Enrollment · participants290Actual

Source updated2026-07-24Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Posted 2026-07-24 · 4 fields changed

Participant count type changed

− Before

~~Estimated~~

+ After

Actual

Enrollment · participant count changed

− Before

~~276 participants (planned)~~

+ After

290 participants (actual)

Primary completion date changed

− Before

~~Dec 2026~~

+ After

Jun 2027

Recruitment status changed

− Before

~~Recruiting~~

+ After

Active not recruiting

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Study details

Conditions studied

Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

Treatments or interventions studied

Not recorded

Primary outcomes · main study measures

measure: Change from Baseline to Month 12 in Xerostomia-specific Questionnaire (XQ) Total Score; description: The XQ consists of 8 symptom-specific questions the participant rates from 0 (not present) to 10 (worst possible). The XQ Total Score is the sum of all individual item ratings and ranges from 0 to 80.; timeFrame: 12 months

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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