NCT05291091Phase 2Completed

Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON)

Study sponsor: Edgewise Therapeutics, Inc. · EWTX

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

Primary completion2026-09-07Actual
Enrollment · participants244Actual
Source updated2026-09-21Last update listed in the registry record
Version history

Changes to this trial

Last 12 months
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· 4 fields changed

Main study measure wording changed

Text changed; whether the study measures changed has not been verified. Saved text may be shortened.

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− Before

Measure: Number of adverse events in those treated with sevasemten or placebo Measure: Severity of adverse events in those treated with sevasemten or placebo Measure: Change from Baseline in serum Creatine Kinase Measure: Change from Baseline in the North Star Ambulatory Assessment scale

+ After

Measure: Number of treatment emergent adverse events in those treated with sevasemten or placebo Measure: Severity of treatment emergent adverse events in those treated with sevasemten or placebo Measure: Change from Baseline in serum Creatine Kinase Measure: Change from Baseline in total North Star Ambulatory Assessment score

Completion date type changed

− Before

Estimated

+ After

Actual

Primary completion date changed

− Before

Sep 2026

+ After

7 Sep 2026

Recruitment status changed

− Before

Active not recruiting

+ After

Completed

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· 1 field changed

Actual enrollment increased by 69 participants

− Before

175 participants (actual)

+ After

244 participants (actual)

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· 1 field changed

Primary completion date changed

− Before

Aug 2026

+ After

Sep 2026

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