NCT05186818Phase 3Completed

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2023-11-10Actual

Enrollment · participants282Actual

Source updated2026-03-03Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Posted 2026-02-02 · 1 field changed

Main study measure wording changed

Text changed; whether the study measures changed has not been verified. Saved text may be shortened.

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− Before

Measure: Change in ~~peak~~ ~~oxygen~~ ~~uptake~~ ~~(pVO2) by cardiopulmonary exercise testing (CPET)~~

+ After

Measure: Change From Baseline in pVO2 at Week 24

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Study details

Conditions studied

Obstructive Hypertrophic Cardiomyopathy (oHCM)

Treatments or interventions studied

Aficamten (5 mg, 10 mg, 15 mg, and 20 mg)DrugAlso known as CK-3773274
Placebo to match aficamtenDrugAlso known as Placebo

Primary outcomes · main study measures

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measure: Change From Baseline in pVO2 at Week 24; description: The effect of CK-3773274 on exercise capacity in participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) was determined through changes in peak oxygen uptake (pVO2) after 24 weeks of treatment. pVO2 was measured by cardiopulmonary exercise testing (CPET) on a treadmill or bicycle. A higher pVO2 indicates better cardiorespiratory fitness.; timeFrame: Baseline to Week 24

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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