NCT04544293Phase 3Active not recruiting

Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2023-11-30Actual

Enrollment · participants164Actual

Source updated2026-08-26Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Study details

Conditions studied

Autoimmune Pulmonary Alveolar Proteinosis

Treatments or interventions studied

MolgramostimDrugAlso known as Recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF)
PlaceboDrugAlso known as Placebo nebulizer
Molgramostim Open-labelDrugAlso known as Recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF)

Primary outcomes · main study measures

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measure: Change From Baseline in Percent (%) Predicted Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) Adjusted for Hemoglobin Concentration to Week 24; description: As a measure of pulmonary gas transfer, a standardized lung function test, DLCO, was conducted. The single-breath DLCO test was performed in accordance with American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines for DLCO testing. Results reported as % predicted DLCO adjusted for hemoglobin concentration (%predicted DLCOadj).; timeFrame: From Baseline to Week 24

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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