NCT04136171Phase 3Completed

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Study sponsor: Ionis Pharmaceuticals, Inc. · IONS

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2026-03-25Actual

Enrollment · participants1438Actual

Source updated2026-09-03Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Posted 2026-08-25 · 3 fields changed

Completion date type changed

− Before

~~Estimated~~

+ After

Actual

Primary completion date changed

− Before

~~Apr 2026~~

+ After

25 Mar 2026

Recruitment status changed

− Before

~~Active not recruiting~~

+ After

Completed

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