NCT04057040Phase 2Completed

Hepcidin Mimetic in Patients With Polycythemia Vera (REVIVE)

Study sponsor: Protagonist Therapeutics, Inc. · PTGX

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2023-02-14Actual

Enrollment · participants70Actual

Source updated2025-08-07Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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No recorded changes are available for this view and time period. Our history may be incomplete; this does not establish that the trial stayed unchanged.

Study details

Conditions studied

Polycythemia Vera

Treatments or interventions studied

PTG-300Drug
PlaceboDrug

Primary outcomes · main study measures

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measure: Proportion of responders during the blinded randomized withdrawal period (Week 29 to Week 41).; description: A subject will be considered a responder during the blinded randomized withdrawal phase if hematocrit control is maintained without phlebotomy eligibility. "Phlebotomy eligibility" is defined as any one of the following criteria being met: * hematocrit ≥45% that was ≥3% higher than Week 29 pre-randomization hematocrit value, or * hematocrit \>48%, or * an increase of ≥5% in hematocrit compared to Week 29 pre-randomization hematocrit value.; timeFrame: 12 weeks

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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