NCT03414034Phase 2Completed

Onvansertib in Combination With Abiraterone and Prednisone in Adult Patients With Metastatic Castration-Resistant Prostate Cancer

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2023-10-16Actual

Enrollment · participants72Actual

Source updated2024-11-07Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Study details

Conditions studied

Metastatic Castration-Resistant Prostate Cancer

Treatments or interventions studied

OnvansertibDrugAlso known as PCM-075
AbirateroneDrug
PrednisoneDrug

Primary outcomes · main study measures

Read the study measures

measure: Percentage of Participants Achieving Disease Control at or Before 12 Weeks; description: Disease control was defined as lack of prostate-specific antigen (PSA) progression per Prostate Cancer Working Group 3 (PCWG3) criteria: not having an increase in PSA from Baseline or nadir ≥ 25% and ≥ 2 ng/mL during the first 12 weeks of PSA assessments. Participants that do not have 12 weeks of PSA assessments were considered not to have demonstrated PSA progression control in this analysis. If a participant achieved disease control prior to Week 12, but relapsed at, or before Week 12, disease control was still considered achieved. The 90% confidence intervals were calculated using Wilson Confidence Interval.; timeFrame: Baseline up to Week 12

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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