NCT03377179Phase 2Completed

A Study of ABC294640 Alone and in Combination With HCQ Sulfate in the Treatment of Advanced Cholangiocarcinoma

Study sponsor: RedHill Biopharma Limited

Compare the available registry edits below. Primary completion is the date data collection ends for the main study measures; it does not tell you when results will be published.

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Primary completion2022-06-21Actual

Enrollment · participants65Actual

Source updated2025-07-23Last update listed in the registry record

Version history

Changes to this trial

Last 12 months

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Study details

Conditions studied

Cholangiocarcinoma; Cholangiocarcinoma Non-resectable; Cholangiocarcinoma, Perihilar; Cholangiocarcinoma, Extrahepatic; Cholangiocarcinoma, Intrahepatic

Treatments or interventions studied

ABC294640DrugAlso known as yeliva, opaganib
Hydroxychloroquine Sulfate 200 MGDrugAlso known as HCQ

Primary outcomes · main study measures

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measure: Part1 - Determine Response Rate; description: To determine the response rate (RR) of CCA defined as objective responses (OR), i.e. complete and partial responses (CR, PR) plus stable disease (SD) of at least 4 months to treatment with ABC294640.; timeFrame: At least 4 months; measure: Part 2 - Determine the Durable Disease Control Rate; description: To determine the Durable Disease Control Rate (DDCR) of CCA defined as Disease Control Rate (DCR) of at least 4 months duration to treatment with ABC294640 and HCQ; timeFrame: At least 4 months

History coverage

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

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