Sponsors / PYPD
PYPD

PolyPid Ltd.

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4Trials in this database
9Recorded changes · last 12 months
Partial coverageOnly the trials and history collected so far

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

Completion dates · Pro

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Pro summarizes how far estimated completion dates moved later and counts trials with edits to their main study measures, using the history available here. View Pro features

Included trials

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TrialSponsorPhaseStatusPrimary completion
D-PLEX 302: Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac SurgeryNCT03558984PYPDPhase 3Terminated2022-10-24Actual
D-PLEX 310: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional InfectionNCT03633123PYPDPhase 2Completed2019-09-06Actual
D-PLEX 311: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional InfectionNCT04233424PYPDPhase 3Completed2022-09-02Actual
D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)NCT04411199PYPDPhase 3Completed2025-04-14Actual

Latest recorded trial changes

D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)

NCT04411199 · PolyPid Ltd.

· 1 field changed

Main study measure wording changed

Text changed; whether the study measures changed has not been verified. Saved text may be shortened.

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− Before

Measure: Infection Rate as Measured by the Proportion of Subjects With an Surgical Site Infection (SSI) Event in the Population of Subjects With Target Incision Length >20 cm

+ After

Measure: Infection Rate as Measured by the Percentage of Subjects With SSI Event in the Target Incision Within 30 Days Post Index Surgery or Re-interventions or Death [for Any Reason] in the Population of Subjects With Target Incision Length >20 cm

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D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)

NCT04411199 · PolyPid Ltd.

· 2 fields changed

Main study measure wording changed

Text changed; whether the study measures changed has not been verified. Saved text may be shortened.

Compare wording
− Before

Measure: To assess the anti-infective efficacy of D-PLEX over a period of 30 days post operation, by preventing surgical site infection (SSI), defined as superficial and deep infection, in the target incision(s), compared to the SoC treated control. Measure: Safety of D-PLEX in Prevention of Post Abdominal Surgery Measure: Safety of D-PLEX in Prevention of Post Abdominal Surgery Incisional

+ After

Measure: Infection Rate as Measured by the Proportion of Subjects With an Surgical Site Infection (SSI) Event in the Population of Subjects With Target Incision Length >20 cm

Actual enrollment increased by 175 participants

− Before

800 participants (actual)

+ After

975 participants (actual)

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D-PLEX 310: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection

NCT03633123 · PolyPid Ltd.

· 2 fields changed

Main study measure wording changed

Text changed; whether the study measures changed has not been verified. Saved text may be shortened.

Compare wording
− Before

Measure: Infection rate as measured by the proportion of subjects with abdominal incisional infection event

+ After

Measure: The Combined Infection and Mortality Rate Within 30 Days Post Index Surgery

Actual enrollment increased by 2 participants

− Before

200 participants (actual)

+ After

202 participants (actual)

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