NMRA

Neumora Therapeutics, Inc.

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6Trials in this database

19Recorded changes · last 12 months

Partial coverageOnly the trials and history collected so far

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

Completion dates · Pro

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Included trials

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Trial	Sponsor	Phase	Status	Primary completion
Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs PlaceboNCT04221230	NMRA	Phase 2	Completed	2022-04-08Actual
Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive DisorderNCT06029426	NMRA	Phase 3	Completed	2024-12-03Actual
Study to Assess the Safety and Effectiveness of NMRA-335140-501NCT06029439	NMRA	Phase 3	Terminated	2026-08-17Actual
Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive DisorderNCT06058013	NMRA	Phase 3	Completed	2026-05-06Actual
Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive DisorderNCT06058039	NMRA	Phase 3	Completed	2026-05-04Actual
To Evaluate the Effects of NMRA-335140 on Symptoms of Major Depression in Participants With Bipolar II Disorder.NCT06429722	NMRA	Phase 2	Completed	2025-04-09Actual

Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo

NMRACompletedPrimary completion: 2022-04-08 · Actual

Trial details

Registry ID: NCT04221230
Phase: Phase 2

Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

NMRACompletedPrimary completion: 2024-12-03 · Actual

Trial details

Registry ID: NCT06029426
Phase: Phase 3

Study to Assess the Safety and Effectiveness of NMRA-335140-501

NMRATerminatedPrimary completion: 2026-08-17 · Actual

Trial details

Registry ID: NCT06029439
Phase: Phase 3

Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

NMRACompletedPrimary completion: 2026-05-06 · Actual

Trial details

Registry ID: NCT06058013
Phase: Phase 3

Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder

NMRACompletedPrimary completion: 2026-05-04 · Actual

Trial details

Registry ID: NCT06058039
Phase: Phase 3

To Evaluate the Effects of NMRA-335140 on Symptoms of Major Depression in Participants With Bipolar II Disorder.

NMRACompletedPrimary completion: 2025-04-09 · Actual

Trial details

Registry ID: NCT06429722
Phase: Phase 2

Latest recorded trial changes

Study to Assess the Safety and Effectiveness of NMRA-335140-501

NCT06029439 · Neumora Therapeutics, Inc.

Posted 2026-09-14 · 5 fields changed

Participant count type changed

− Before

~~Estimated~~

+ After

Actual

Enrollment · participant count changed

− Before

~~1000 participants (planned)~~

+ After

904 participants (actual)

Completion date type changed

− Before

~~Estimated~~

+ After

Actual

Primary completion date changed

− Before

~~Jun 2027~~

+ After

17 Aug 2026

Recruitment status changed

− Before

~~Active not recruiting~~

+ After

Terminated

Check registry source

Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

NCT06058013 · Neumora Therapeutics, Inc.

Posted 2026-07-06 · 5 fields changed

Participant count type changed

− Before

~~Estimated~~

+ After

Actual

Enrollment · participant count changed

− Before

~~332 participants (planned)~~

+ After

430 participants (actual)

Completion date type changed

− Before

~~Estimated~~

+ After

Actual

Primary completion date changed

− Before

~~May 2026~~

+ After

6 May 2026

Recruitment status changed

− Before

~~Active not recruiting~~

+ After

Completed

Check registry source

Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder

NCT06058039 · Neumora Therapeutics, Inc.

Posted 2026-07-06 · 5 fields changed

Participant count type changed

− Before

~~Estimated~~

+ After

Actual

Enrollment · participant count changed

− Before

~~332 participants (planned)~~

+ After

422 participants (actual)

Completion date type changed

− Before

~~Estimated~~

+ After

Actual

Primary completion date changed

− Before

~~May 2026~~

+ After

4 May 2026

Recruitment status changed

− Before

~~Active not recruiting~~

+ After

Completed

Check registry source

Study to Assess the Safety and Effectiveness of NMRA-335140-501

NCT06029439 · Neumora Therapeutics, Inc.

Posted 2026-06-09 · 1 field changed

Recruitment status changed

− Before

~~Recruiting~~

+ After

Active not recruiting

Check registry source

Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

NCT06058013 · Neumora Therapeutics, Inc.

Posted 2026-04-08 · 1 field changed

Recruitment status changed

− Before

~~Recruiting~~

+ After

Active not recruiting

Check registry source

Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder

NCT06058039 · Neumora Therapeutics, Inc.

Posted 2026-04-08 · 2 fields changed

Primary completion date changed

− Before

~~Feb 2026~~

+ After

May 2026

Recruitment status changed

− Before

~~Recruiting~~

+ After

Active not recruiting

Check registry source