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JAZZ

Jazz Pharmaceuticals

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30Trials in this database
16Recorded changes · last 12 months
Partial coverageOnly the trials and history collected so far

Research sample: selected versions from May 2023 onward plus a preceding baseline where available. Only selected fields were retained; endpoint measures were truncated to 300 characters. This is not complete trial or sponsor history. Daily snapshots begin when collection starts.

Completion dates · Pro

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Pro summarizes how far estimated completion dates moved later and counts trials with edits to their main study measures, using the history available here. View Pro features

Included trials

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TrialSponsorPhaseStatusPrimary completion
Oral ONC201 in Adult Recurrent GlioblastomaNCT02525692Jazz PharmaceuticalsPhase 2Terminated2023-04-17Actual
Dociparstat Sodium (CX-01) Combined With Standard Induction Therapy for Newly Diagnosed Acute Myeloid LeukemiaNCT02873338Jazz PharmaceuticalsPhase 2Completed2019-06Actual
ONC201 in Adults With Recurrent H3 K27M-mutant GliomaNCT03295396Jazz PharmaceuticalsPhase 2Terminated2022-12-31Actual
ONC201 in Recurrent or Metastatic Type II Endometrial Cancer Endometrial CancerNCT03485729Jazz PharmaceuticalsPhase 2Terminated2023-01-19Actual
A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal CancerNCT03929666Jazz PharmaceuticalsPhase 2Completed2025-08-30Actual
An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)NCT04145531Jazz PharmaceuticalsPhase 2, Phase 3Completed2022-07-13Actual
Safety and Effectiveness of Nabiximols Oromucosal Spray as Add-on Therapy in Participants With Spasticity Due to Multiple SclerosisNCT04203498Jazz PharmaceuticalsPhase 3Terminated2023-02-10Actual
Phase 2a Study of ZW25 in Combination With Palbociclib Plus FulvestrantNCT04224272Jazz PharmaceuticalsPhase 2Completed2023-04-28Actual
Trial to Investigate the Safety and Efficacy of GWP42003-P Versus Placebo as Adjunctive Therapy in Participants With Schizophrenia Experiencing Inadequate Response to Ongoing Antipsychotic TreatmentNCT04421456Jazz PharmaceuticalsPhase 2Terminated2022-03-16Actual
A Study of ZW25 (Zanidatamab) in Subjects With Advanced or Metastatic HER2-Amplified Biliary Tract CancersNCT04466891Jazz PharmaceuticalsPhase 2Completed2023-07-28Actual
Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled SeizuresNCT04485104Jazz PharmaceuticalsPhase 3Terminated2025-01-28Actual
Dociparstat in Combination With Standard Chemotherapy for the Treatment of Acute Myeloid LeukemiaNCT04571645Jazz PharmaceuticalsPhase 3Terminated2022-05-16Actual
Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple SclerosisNCT04657666Jazz PharmaceuticalsPhase 3Completed2022-05-04Actual
Trial to Investigate the Safety and Efficacy of Cannabidiol Oral Solution (GWP42003-P; CBD-OS) in Children and Adolescents With Autism Spectrum DisorderNCT04745026Jazz PharmaceuticalsPhase 2Completed2023-12-21Actual
Evaluation of the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple SclerosisNCT04984278Jazz PharmaceuticalsPhase 3Terminated2022-11-11Actual
A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)NCT05122650Jazz PharmaceuticalsPhase 2Completed2024-05-30Actual
Lurbinectedin Monotherapy in Participants With Advanced or Metastatic Solid TumorsNCT05126433Jazz PharmaceuticalsPhase 2Terminated2023-12-20Actual
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal CancersNCT05152147Jazz PharmaceuticalsPhase 3Active not recruiting2026-07-15Actual
A Study of JZP150 in Adults With Posttraumatic Stress DisorderNCT05178316Jazz PharmaceuticalsPhase 2Completed2023-12-05Actual
Efficacy and Safety of GWP42003-P Oral Solution in Children With Epilepsy With Myoclonic-atonic SeizuresNCT05288283Jazz PharmaceuticalsPhase 3Terminated2023-09-28Actual
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)NCT05580562Jazz PharmaceuticalsPhase 3Recruiting2028-06Estimated
A Study of Suvecaltamide in Adults With Moderate to Severe Residual Tremor in Parkinson's DiseaseNCT05642442Jazz PharmaceuticalsPhase 2Completed2024-10-23Actual
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract CancerNCT06282575Jazz PharmaceuticalsPhase 3Recruiting2028-12-01Estimated
A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast CancerNCT06435429Jazz PharmaceuticalsPhase 3Recruiting2028-04-28Estimated
A Phase 2 Study of Zanidatamab in Patients With HER2-expressing TumorsNCT06695845Jazz PharmaceuticalsPhase 2Recruiting2026-12-31Estimated
A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast CancerNCT07102381Jazz PharmaceuticalsPhase 2Recruiting2028-01-01Estimated
Study of ONC206 (JZP3507) in Advanced Pheochromocytoma and ParagangliomaNCT07282587Jazz PharmaceuticalsPhase 2Recruiting2028-12-15Estimated
A Study of Lurbinectedin in Combination With Durvalumab for the Treatment of Participants With ES-SCLCNCT07459634Jazz PharmaceuticalsPhase 2Recruiting2028-01-31Estimated
A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 MeningiomaNCT07533942Jazz PharmaceuticalsPhase 2Recruiting2028-10-25Estimated
A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IHNCT07625280Jazz PharmaceuticalsPhase 3Recruiting2027-12-23Estimated

Latest recorded trial changes

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

NCT05580562 · Jazz Pharmaceuticals

· 3 fields changed

Main study measure wording changed

Text changed; whether the study measures changed has not been verified. Saved text may be shortened.

Compare wording
− Before

Measure: Overall survival (OS) Measure: Progression free survival (PFS) as assessed by using RANO-HGG criteria

+ After

Measure: Overall survival (OS)

Planned enrollment increased by 60 participants

− Before

450 participants (planned)

+ After

510 participants (planned)

Primary completion date changed

− Before

Aug 2026

+ After

Jun 2028

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A Study of Suvecaltamide in Adults With Moderate to Severe Residual Tremor in Parkinson's Disease

NCT05642442 · Jazz Pharmaceuticals

· 1 field changed

Main study measure wording changed

Text changed; whether the study measures changed has not been verified. Saved text may be shortened.

Compare wording
− Before

Measure: Change from Baseline to Week 17 on the Essential Tremor Rating Scale (TETRAS) Composite Outcome Score

+ After

Measure: Change From Baseline to Week 17 on the Essential Tremor Rating Scale (TETRAS) Composite Outcome Score

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